Sanger.ac.uk

Detailed map of the heart provides new insights into cardiac …

WebThis map acts as a molecular guidebook, showing what healthy cells look like, and providing a crucial reference to understand what goes wrong in disease. The findings will help understand diseases such as those affecting the heart rhythm. The assembly of a Human Heart Cell Atlas is key given that cardiovascular diseases are the leading cause …

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URL: https://www.sanger.ac.uk/news_item/detailed-map-of-the-heart-provides-new-insights-into-cardiac-health-and-disease/

World’s largest genetic project opens the door to new era for

WebUK Biobank is a large-scale biomedical database and research resource containing de-identified genetic, lifestyle and health information and biological samples from half a million UK participants. It is the most comprehensive and widely-used dataset of its kind, and is globally accessible to approved researchers who are undertaking health …

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Genomics campus expansion to boost science in UK and health …

Web2) Urban&Civic is a leading master developer of high-quality, large-scale sites. The business was established in 2009 and acquired by Wellcome in 2021. It forms part of Wellcome’s investment portfolio, helping Wellcome fund science to solve urgent health challenges by delivering sustainable developments that create long-term value …

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Genes and Health

WebGenes & Health is a research study set up to help fight against these and other major diseases. We are currently recruiting volunteers in East London Genes & Health (2015-), Bradford Genes & Health (2019-) and Manchester Genes & Health (commences 2020).

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500,000 whole human genomes will be a game-changer for …

WebIn a major advance for public health and for the UK’s global leadership in genomics, a £200m project involving the government, charity, researchers and four leading pharmaceutical companies, was announced today (11 September). The Whole Genome Sequencing (WGS) project will become a game-changing resource accessible to the …

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Wellcome Sanger Institute

WebWe apply and explore genomic technologies at scale to advance understanding of biology and improve health Source of pregnancy complications from infections revealed by placenta map The placenta’s response to infections from malaria, toxoplasmosis and listeria has been mapped in high resolution for the first time, possibly …

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New hub to help make global genomic surveillance of disease a …

WebA new global hub for genomic surveillance has been launched today by the Wellcome Sanger Institute, which will work with partners around the world to use genome sequencing to help tackle infectious diseases, including SARS-CoV-2 and malaria. The Genomic Surveillance Unit (GSU) will work closely with its partners to help develop their …

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Highly detailed map of human heart could guide personalised …

WebPublished today in Nature (24 September), this study is part of the Human Cell Atlas initiative to map every cell type in the human body. The new molecular and cellular knowledge of the heart will enable better understanding of heart disease and guide more personalised medicine. It could also potentially lead to regenerative medicine in the …

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Health Data Research UK (HDR UK)

WebThe Health Data Research (HDR) UK Cambridge site is part of the national institute for health data science (HDR UK) and comprises the Wellcome Sanger Institute, EMBL-EBI, the University of Cambridge and its hospitals. HDR UK Cambridge aims to advance understanding of disease prediction, causation, and progression through the integration …

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Health Data Research UK

WebHealth Data Research UK (HDR-UK) is the national institute for health data science. HDR-UK is uniting the UK’s health data to enable discoveries that improve people’s lives. By making health data available to researchers and innovators we can better understand diseases and find ways to prevent, treat and cure them.

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COVID-19 Genomics UK (COG-UK) Consortium

WebThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, represented a major threat to health. The COVID-19 Genomics UK (COG-UK) Consortium was been created to deliver large-scale and rapid whole-genome virus sequencing to local NHS centres and the UK government. Its data helped Public Health Agencies to manage the COVID-19 outbreak …

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How Dantu blood group protects against malaria – and how all …

WebMalaria remains a major global health problem causing an estimated 435,000 deaths per year, with 61 per cent occurring in children under five years of age. P. falciparum is responsible for the deadliest form of malaria and is particularly prevalent in Africa, accounting for 99.7 per cent of African malaria cases and 93 per cent of global

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Cellular Genetics

WebThe Cellular Genetics programme is focused on cell-atlasing and cellular genetics. The programme uses these approaches to map cells in the human body combining cutting-edge methodologies and computational approaches. This enables us to understand what the identity of cells are, how they are regulated, relationships between them and, importantly

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Human respiratory pathogens will be tracked in new initiative

WebA new initiative to better understand respiratory viruses has been launched today by the Wellcome Sanger Institute. The new Respiratory Virus & Microbiome Initiative will lay the groundwork for large-scale genomic surveillance of respiratory viruses, building on the Institute’s genomics expertise and the experience gained sequencing millions of …

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Whole Genome Sequencing data on 200,000 UK Biobank …

WebThese data, combined with the extensive lifestyle, biochemical and health outcome data already available, makes the UK Biobank an increasingly powerful resource for understanding the genetic architecture of diseases and accelerating drug discovery and development. It is a truly pivotal moment for scientific research aimed at improving …

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Accumulation of DNA mutations found in healthy liver leads to …

WebResearchers discovered that these signatures of DNA mutations are also present in healthy and diseased liver, and that it is the accumulation of changes from these signatures that ultimately leads to serious health problems. The study, published today in Nature, is the largest study of the differences in genetic changes between healthy and

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Genomics and genome editing in the NHS

WebLocal health outbreaks should be sequenced in regional centres with information shared with and by PHE. National or international level surveillance and outbreaks should be centrally handled by PHE. Recommendation: Data standards should be mandated and raw data should be made accessible to research and the public health communities.

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Project finds 12 new genetic causes of developmental disorders

WebSelected websites. The Health Innovation Challenge Fund. The Health Innovation Challenge Fund is a parallel funding partnership between the Wellcome Trust and the Department of Health to stimulate the creation of innovative healthcare products, technologies and interventions and to facilitate their development for the benefit of …

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Development study reveals origins of Inflammatory Bowel Disease

WebA new large-scale study mapped the cells in the human gut from early development through to adulthood, creating the most comprehensive Cell Atlas of the Gut to date. This revealed that Crohn’s disease may be caused by activation of developmental pathways, and uncovered potential drug targets for treating Crohn’s and other …

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MRC Centre for Genomics and Global Health (CGGH)

WebA central problem in infectious disease research is that pathogens are continuously evolving. To understand the genomic diversity underpinning diseases like malaria, HIV/AIDS, influenza, and dengue, the Medical Research Council (MRC) supported the creation of the CCGH in 2008. After 13 years of successful collaboration and many high-profile

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