Jpet.aspetjournals.org
Reversal of diet-induced obesity by NLRP3 inhibition
WEBSystemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metabolic impairment. While the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to obesity-associated inflammation, whether it contributes to the development or maintenance of …
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URL: https://jpet.aspetjournals.org/content/early/2024/02/08/jpet.123.002013
L-Arginine Enhances the Effects of Cardiac Rehabilitation …
WEBCardiac rehabilitation (CR) following acute myocardial infarction (AMI) improves physical capacities and decreases hospitalizations and cardiovascular mortality. L-Arginine is the substrate used by nitric oxide (NO) synthase (NOS) to generate NO and it has been shown to exert its beneficial effects on endothelium driving vasodilatation, …
Protoporphyrin IX: the Good, the Bad, and the Ugly
WEBProtoporphyrin IX (PPIX) is ubiquitously present in all living cells in small amounts as a precursor of heme. PPIX has some biologic functions of its own, and PPIX-based strategies have been used for cancer diagnosis and treatment (the good). PPIX serves as the substrate for ferrochelatase, the final enzyme in heme biosynthesis, and …
NAD+ and Vitamin B3: From Metabolism to Therapies
WEBThe role of NAD+ metabolism in health and disease is of increased interest as the use of niacin (nicotinic acid) has emerged as a major therapy for treatment of hyperlipidemias and with the recognition that nicotinamide can protect tissues and NAD+ metabolism in a variety of disease states, including ischemia/reperfusion. In addition, a …
Mitochondrial Dysfunction in Neurodegenerative Diseases
WEBNeurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired …
The Opioid Crisis and the Future of Addiction and Pain …
WEBOpioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and significant social and economic impact. Curbing this crisis requires collaboration among academic, government, and industrial partners toward the development of effective nonaddictive pain medications, interventions for opioid …
Physiologic, Metabolic, and Toxicologic Profile of 1,3 …
WEBKetone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity. β -hydroxybutyrate ( β HB) is the most abundant ketone body. The secondary alcohol, 1,3-butanediol (1,3-BD), is commonly administered to raise β HB bioavailability …
Physiologic, metabolic, and toxicologic profile of 1,3 …
WEBKetone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity. β-hydroxybutyrate (βHB) is the most abundant ketone body. The secondary alcohol, 1,3-butanediol (1,3-BD), is commonly administered to raise βHB bioavailability …
Dual sEH/FAAH Inhibitors as a Promising Therapeutic …
WEBAbstract ID 21553 Poster Board 90 Chronic pain is the primary cause of disability worldwide. According to the National Institutes of Health, nearly 25.3 million Americans suffer from daily pain, and another 23.4 million Americans report significant pain. In this project we developed dual inhibitors, single small molecules that simultaneously …
Conquering Metabolic Syndrome: Navigating Pharmacological …
WEBMetabolic syndrome (MetS) represents a constellation of interrelated metabolic disturbances, including insulin resistance, central obesity, dyslipidemia, and hypertension, which collectively increase the risk of cardiovascular disease and type 2 diabetes mellitus (Alberti et al., 2009).With the global prevalence of MetS on the rise, it …
The Pharmacological Case for Cannabigerol Journal of …
WEBMedical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), are receiving growing attention in both the media and the scientific literature. The Cannabis plant, however, produces over 100 different cannabinoids, and cannabigerol (CBG) serves as the precursor molecule …
Role of Cannabinoid Signaling in Cardiovascular Function and …
WEBCardiovascular disease represents a leading cause of death, morbidity, and societal economic burden. The prevalence of cannabis use has significantly increased due to legalization and an increased societal acceptance of cannabis. Therefore, it is critically important that we gain a greater understanding of the effects and risks of cannabinoid …
Inhibition of Glucose-6-Phosphate Dehydrogenase Activity …
WEBPulmonary hypertension (PH) is a disease of hyperplasia of pulmonary vascular cells. The pentose phosphate pathway (PPP)—a fundamental glucose metabolism pathway—is vital for cell growth. Because treatment of PH is inadequate, our goal was to determine whether inhibition of glucose-6-phosphate dehydrogenase (G6PD), the rate …
Influence of Opioid Agonists on Cardiac Human
WEBWe have evaluated the ability of various opioid agonists, including methadone, l-α-acetylmethadol (LAAM), fentanyl, meperidine, codeine, morphine, and buprenorphine, to block the cardiac human ether-a-go-go -related gene (HERG) K+current (IHERG) in human cells stably transfected with the HERG potassium channel gene. Our …
The Journal of Pharmacology and Experimental Therapeutics
WEBA Publication of the American Society for Pharmacology and Experimental Therapeutics. Founded by John J. Abel - 1908 . EDITOR. Beverley Greenwood-Van Meerveld, University of Oklahoma Health Sciences Ctr, Gastrointestinal Pharmacology MINIREVIEWS EDITOR
Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the
WEBEtavopivat is an investigational, oral, small molecule activator of erythrocyte pyruvate kinase (PKR) in development for the treatment of sickle cell disease (SCD) and other hemoglobinopathies. PKR activation is proposed to ameliorate the sickling of SCD red blood cells (RBCs) through multiple mechanisms, including reduction of 2,3 …
The Role of Smoking and Nicotine in the Transmission and …
WEBCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 virus, is turning out to be one of the most devastating global pandemics in the history of humankind. There is a shortage of effective therapeutic strategies or preventative vaccines for this disease to date. A rigorous investigation is …
Category: Coronavirus Go Health
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