Journals.physiology.org

Exercise and health: historical perspectives and new insights

WEBSince ancient times, the health benefits of regular physical activity/exercise have been recognized and the classic studies of Morris and Paffenbarger provided the …

Actived: 2 days ago

URL: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00242.2021

Physical Activity, Aging, and Physiological Function

WEBHuman evolution suggests that the default position for health is to be physically active. Inactivity, by contrast, has serious negative effects on health across …

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Mitochondria in health, disease, and aging Physiological …

WEBMitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

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High-Intensity Exercise and Mitochondrial Biogenesis: …

WEBIntroduction. Mitochondria are double-membrane organelles that generate cellular energy via oxidative phosphorylation (OXPHOS). In skeletal muscle, they range …

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Genetic mechanisms of human hypertension and their …

WEBHypertension, or elevated blood pressure, constitutes a major public health burden that affects more than 1 billion people worldwide and contributes to ~9 million …

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Human temperature regulation under heat stress in …

WEBThe human body constantly exchanges heat with the environment. Temperature regulation is a homeostatic feedback control system that ensures deep …

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Mitochondrial DNA damage as driver of cellular outcomes

WEBMitochondria are primarily involved in energy production through the process of oxidative phosphorylation (OXPHOS). Increasing evidence has shown that …

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Humor, laughter, learning, and health! A brief review

WEBHuman emotions, such as anxiety, depression, fear, joy, and laughter, profoundly affect psychological and physiological processes. These emotions form a set …

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Magnesium in Man: Implications for Health and Disease

WEBMagnesium (Mg2+) is an essential ion to the human body, playing an instrumental role in supporting and sustaining health and life. As the second most abundant intracellular …

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Interactive effects of exercise intensity and recovery …

WEBPost-exercise reduction in blood pressure, termed post-exercise hypotension (PEH), is relevant for both acute and chronic health reasons and potentially for …

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COPD 2020: changes and challenges American Journal of …

WEBINTRODUCTION. Chronic obstructive pulmonary disease (COPD) is a major global health problem due to its high prevalence (about 10% of the adult population), …

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Insights into digestion and absorption of major nutrients in humans

WEBNutrient digestion and absorption is necessary for the survival of living organisms and has evolved into the complex and specific task of the gastrointestinal (GI) …

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Heat therapy: possible benefits for cognitive function and the …

WEBINTRODUCTION. Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting over 5 million Americans, with this number …

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Alkali supplementation as a therapeutic in chronic kidney disease: …

WEBAcidosis in CKD and Its Relationship to GFR Decline. CKD represents an enormous health burden (18a, 96), and new treatments to slow the progression of CKD …

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Physiology in Perspective: A Key Role of Physiology in …

WEBThe renin-angiotensin-aldosterone system (RAAS) is a key homeostatic system within our bodies that involves the brain, lungs, kidneys, and liver to regulate …

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Examining the benefits of cold exposure as a therapeutic strategy …

WEBThe pathogenesis of metabolic diseases such as obesity and type 2 diabetes are characterized by a progressive dysregulation in energy partitioning, often …

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The glycocalyx: a central regulator of vascular function

WEBThe endothelial glycocalyx is a specialized extracellular matrix that covers the apical side of vascular endothelial cells, projecting into the lumen of blood vessels. …

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Bilirubin acts as a multipotent guardian of cardiovascular integrity

WEBBilirubin is generally regarded as a waste product with little or no physiological purpose and can be toxic if it accumulates. However, bilirubin formation in …

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Preeclampsia beyond pregnancy: long-term consequences for …

WEBPreeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with evidence of maternal organ failure. Rates of preeclampsia have …

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