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The impact of rare and low-frequency genetic variants in …

WebDespite thousands of genetic loci identified to date, a large proportion of genetic variation predisposing to complex disease and traits remains unaccounted for. …

Actived: 4 days ago

URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1212-4

Understanding rare and common diseases in the context …

WebThe wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection affect the …

Category:  Health Go Health

The MHC locus and genetic susceptibility to autoimmune …

WebIn the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major …

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Implications for health and disease in the genetic …

WebBackground Relatively small, reproductively isolated populations with reduced genetic diversity may have advantages for genomewide association mapping in …

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Host lifestyle affects human microbiota on daily timescales

WebThe temporal dynamics of host-associated microbial communities (the microbiota) are of growing interest due to these communities’ relevance for health …

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Human disease genomics: from variants to biology

WebThe central objectives of human genetic research are to identify the sequence variation that plays a causal role in the development of disease, and then to …

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Population dynamics of the human gut microbiome: …

WebCharacterization of the temporal dynamics of the human gut microbiome is crucial for understanding its role in modulating host health. Two recent studies explored …

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Host-microbiome protein-protein interactions capture …

WebHost-microbe interactions are crucial for normal physiological and immune system development and are implicated in a variety of diseases, including inflammatory …

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Multi-omics approaches to disease Genome Biology Full Text

WebHigh-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and …

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An obesity-associated gut microbiome reprograms the intestinal

WebThe gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is …

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Applications and potential of genome editing in crop improvement

WebGenome-editing tools provide advanced biotechnological techniques that enable the precise and efficient targeted modification of an organism’s genome. Genome …

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Epidemiologic data and pathogen genome sequences: a powerful …

WebEpidemiologists aim to inform the design of public health interventions with evidence on the evolution, emergence and spread of infectious diseases. Sequencing of …

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Host adaptation in gut Firmicutes is associated with sporulation …

WebThe human gut is colonized by highly adapted bacteria, primarily from the Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria phyla, that are linked with …

Category:  Health Go Health

New insights into the generation and role of de novo mutations in

WebAside from inheriting half of the genome of each of our parents, we are born with a small number of novel mutations that occurred during gametogenesis and …

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Characterizing human lung tissue microbiota and its relationship …

WebThe human lung tissue microbiota remains largely uncharacterized, although a number of studies based on airway samples suggest the existence of a viable human …

Category:  Health Go Health

The plant microbiome Genome Biology Full Text

WebThe rhizosphere is the region of soil influenced by plant roots through rhizodeposition of exudates, mucilage and sloughed cells. Root exudates contain a …

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Deterministic transition of enterotypes shapes the infant gut

WebThe succession of the gut microbiota during the first few years plays a vital role in human development. We elucidate the characteristics and alternations of the …

Category:  Health Go Health

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