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Brain Receptor Structures Key to Future Therapeutics

WebX-ray crystal structure of the NMDA receptor showing its mushroom-like shape, with receptor subunits in different colors. 305gouaux Multiple structures of two …

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URL: https://als.lbl.gov/brain-receptor-structures-key-to-future-therapeutics/

Two Basic Mechanisms of Cardiovascular Drugs

WebThe structures of proteins controlling calcium-ion transport through cell membranes have been revealed, bound to two drugs known as calcium channel …

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A New Pathway for Radionuclide Uptake

WebA New Pathway for Radionuclide Uptake. January 21, 2016. Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, …

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ALS 8.3.1 BL8.3.1

WebALS Beamline 8.3.1 – The “TomAlberTron” Beamline 8.3.1 at the Advanced Light Source is operated by the University of California San Francisco with the support of generous …

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Inhalable COVID-19 Protection via Synthetic Nanobodies

WebStable enough to be used in inhalers or nasal sprays, the nanobodies offer a new option, aside from injected vaccines, for COVID-19 prevention and treatment. Three nanobodies …

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Targeting Bacteria That Cause Meningitis and Sepsis

WebMeningococcal disease. Our central nervous systems (brain and spinal cord) are surrounded by three membranes called “meninges.”. Meningitis is caused by the …

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Experiment Safety

WebSafety at the ALS. Safety is a core value that helps support the mission of the ALS, which is to “advance science for the benefit of society by providing our world-class synchrotron …

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Structure of a Key Protein from the Zika Virus

WebThe Zika virus (ZIKV) is a mosquito-borne pathogen recently linked to birth defects in infants. At the ALS, researchers have resolved the structure of a key ZIKV …

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Jim Floyd, Environment, Health and Safety

WebThe Lab’s Environment, Health and Safety Division continues to reach out to the research community for ideas on how to improve its policies and processes. Many …

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Mapping the Topology of the Human Genome

WebThus, bits of DNA that may be very distant in linear sequence may actually be in close proximity in a living cell. This “topological” proximity can have functional …

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Experimental Drug Targets HIV in a Novel Way

WebA drug with a novel mechanism of action. Most HIV drugs work by blocking viral enzymes—proteins that initiate key steps in the viral life cycle. In contrast, GS‑6207 …

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An Antibody That Broadly Neutralizes SARS-CoV-2

WebAn antibody that appears to neutralize all known SARS-CoV-2 strains and closely related coronaviruses was discovered with the help of the ALS. The work …

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Breakthrough in Membrane-Protein Design Settles Long-Standing …

WebA long-standing debate among scientists is whether van der Waals forces—short-range forces between uncharged molecules—are too weak to stabilize …

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DNA Synthesis: Flip It and Reverse It

WebDNA Synthesis: Flip It and Reverse It. December 2, 2021. Every time our cells divide, the DNA inside must be copied, or synthesized, accurately to avoid mistakes that could be …

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Binding Behavior of Dopamine Transporter Key to Understanding …

WebScientists working at the ALS recently solved the crystallographic structures of several amine transporters in an effort to better understand why the human brain …

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The Effects of Diabetes on Spinal-Column Biomechanics

WebThe Effects of Diabetes on Spinal-Column Biomechanics. Worldwide, the prevalence of diabetes is increasing, leading to a growing global burden in health care …

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How Iron Remediates Arsenic in Groundwater

WebArsenic contamination in groundwater arises from both natural causes as well as common practices in the community and threatens the environment and human health. Iron …

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A Bullfrog’s Powerful Defense Against Toxic Red Tides

WebA Bullfrog’s Powerful Defense Against Toxic Red Tides. July 25, 2019. As climate change raises ocean temperatures, fisheries and public health agencies closely …

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Fundamental Property of Arginine Revealed Through Solvation

WebArginine, an amino acid that has more than 100 isomers, is fragile and becomes fragmented in the gas phase. Advancements in both technique and theory …

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Coral Exoskeleton Growth Begins Inside Living Tissue

WebResearchers have recently discovered some good news: coral skeletons grow by the aggregation of surprisingly large particles that form within the coral’s living …

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